Selected Publications
1. Chafik, D; Bear, D; Bui, P; Patel, A; Kim, BT; Jones, NF; Hung, CT; Gupta, R:
Optimization of Schwann Cell Adhesion for Peripheral Nerve Tissue Engineering. Tissue
Engineering 9(2): 233-243, 2003. PMID: 12740086
2. Gupta, R; Steward, O. Chronic nerve compression induces concurrent proliferation and
apoptosis of Schwann cells. Journal of Comparative Neurology 461(2): 174-86, June 23,
2003. PMID: 12724836
3. Gupta, R; Lin, Y; Bui, P; Chao, T; Preston, C; Mozzafar, T: Macrophage recruitment follows
the pattern of inducible nitric oxide synthase expression in a model for carpal tunnel
syndrome. Journal of Neurotrauma 20(7): 671-680, 2003; PMID: 12908928
4. Gupta, R; Rowshan, K; Mozaffar, T; Steward, O: Chronic Nerve Compression Induces
Segmental Demyelination in a Rat Model of Carpal Tunnel Syndrome. Experimental
Neurology 187(2): 500-508, 2004; PMID: 15144876
5. Rummler, LR; Gupta, R: Peripheral nerve repair: a review. Current Opinion in Orthopaedics
15(4): 215-219, 2004.
6. Azanchi, R; Bernal, G; Gupta, R; Keirstead, HS: Combined demyelination plus Schwann
cell transplantation therapy increases spread of cells and axonal regeneration following
contusion injury. Journal of Neurotrauma 21(6): 775-788, 2004. PMID: 15253804
7. Rummler, LS; Dinh, PT; Gupta, R. The anatomy and biochemistry of myelin and
myelination. Operative Techniques in Orthopaedics 14(3): 146-152, 2004.
8. Rowshan, K; Jones, NF, Gupta, R. Current Surgical Techniques in Nerve Repair. Operative
Techniques in Orthopaedics 14(3): 163-170, 2004.
9. Dinh, PT; Gupta, R. Subtotal Medial Epicondylectomy as a Surgical option for treatment of
Cubital Tunnel Syndrome. Techniques in Hand & Upper Extremity Surgery 9(1): 52-59,
2005; PMID: 16092820
10. Gupta, R; Gray, M; Chao, T; Bear, D; Modafferri, E; Mozaffar, T. Schwann cells upregulate
vascular endothelial growth factor secondary to chronic nerve compression injury.
Muscle Nerve 31(4): 452-60, 2005; PMID: 15685607
11. Gupta, R; Rummler, L; Steward, O. Understanding the biology of compressive neuropathies.
Clinical Orthopaedics and Related Research 436:251-260, June 2005.
12. Gupta, R; Truong, L; Bear, D; Chafik, D; Modafferi, E; Hung, CT: Shear stress alters
Schwann cell expression of myelin associated glycoprotein (MAG) and myelin basic protein
(MBP). Journal of Orthopaedic Research 23:1232-1239, 2005. PMID: 16140204
13. Gupta, R; Chanual, J. Spatiotemporal pattern of macrophage recruitment after chronic nerve
compression injury. Journal of Neurotrauma 23(2): 216-226, 2006. PMID: 16503805
14. Gupta, R; Rummler, LS; Palispis, W; Chao, T; Truong, L; Steward, O: Local downregulation
of myelin-associated glycoprotein permits axonal sprouting with chronic nerve
compression injury. Experimental Neurology 200(2): 418-29, 2006. Epub 2006 Jun 9;
PMID: 16764860
15. Berger, B; Gupta, R. Demyelination after chronic nerve compression injury alters SchmidtLaterman
Incisures. Journal of Anatomy 209:111-118, 2006.
16. Rasouli, A; Bhatia, N; Souryadevara, S; Cahill, K; Gupta, R. Transplantation of preconditioned
Schwann cells in peripheral nerve grafts following contusion injury to the adult
spinal cord improves recovery in a rat model. Journal of Bone and Joint Surgery 88A(11):
2400-2410, 2006; PMID: 17079397
17. Gray, M; Palispis, W; Popovich, PG; van Rooijen, N; Gupta,R. Macrophage depletion alters
the blood nerve barrier without affecting Schwann cell function after neural injury. Journal
of Neuroscience Research 85(4): 766-777, 2007. [Epub ahead of print January 31, 2007];
PMID: 17266098. Cover Image for the Journal is from this manuscript.
18. Dinh, PT; Bhatia, N; Souryadevara, S; Cahill, K; Gupta, R. Transplantation of preconditioned
Schwann cells in peripheral nerve grafts following hemisection spinal cord
injury. Spine 32(9): 943-9, 2007; PMID: 17450067
19. Gupta, R; Lee, TQ. Contributions of the Different Rabbit Models to our Understanding of
Rotator Cuff Pathology. Journal of Shoulder and Elbow Surgery 16(5): 149S-157S,
September/October 2007; PMID: 17903710
20. Strandberg, E; Mozaffar, T; Gupta, R. The Role of Electrodiagnostic Studies in Nerve
Injuries and other Orthopaedic Disorders. Journal of Hand Surgery 32A(8): 1280-1290,
2007; PMID: 17923316
21. Chao, T; Pham, K; Steward, O; Gupta, R. Chronic nerve compression injury induces a
phenotypic switch of neurons within the dorsal root ganglia. Journal of Comparative
Neurology 506:180-193, 2008; PMID: 18022951
22. Tafti, M; Cramer, S; Gupta, R. Orthopaedic Management of the Upper Extremity in Stroke
Patients. Journal of the American Academy of Orthopaedic Surgery 16(8): 462-70. 2008;
PMID: 18664635
23. Mozaffar T, Strandberg E, Abe K, Hilgenberg LG, Smith MA, Gupta R. Neuromuscular
junction integrity after chronic nerve compression injury. Journal of Orthopaedic Research
27(1): 114-9, Jan 2009; 2008 Jul 24. [Epub ahead of print]; PMID:18655131
24. Rasouli A, Bhatia N, Dinh P, Cahill K, Suryadevara S, Gupta R. Resection of glial scar
following spinal cord injury. Journal of Orthopaedic Research 27(7): 931-6; July,
2009.PMID: 19062171
25. Pham, KD and Gupta, R. Understanding the mechanisms of entrapment neuropathies.
Neurosurgical Focus 26(2): E7, February, 2009.
26. Grumet, RC; Hadley, S; Diltz, MV; Lee, TQ; Gupta, R. Development of a Novel Model for
Rotator Cuff Pathology: The Rabbit Subscapularis Muscle. Acta Orthopaedica 80(1): 97-
103, 2009 Feb; PMID: 19234889
27. Dinh, PT; Hazel, A; Palispis, W; Gupta, R. Functional Assessment after Sciatic Nerve
Injury. Microsurgery 29(8): 644-649; 2009 Aug 3. [Epub ahead of print] PMID: 19653327
28. Frieboes LR and Gupta R. An in vitro traumatic model to evaluate the response of
myelinated cultures to sustained hydrostatic compression injury. Journal of Neurotrauma
26(12): 2245-56, Dec 2009. [Epub 2009 Jul 31] PMID: 19645529
29. Pham, KD; Nassirin, N; Gupta, R. c-Jun, krox-20, and integrin beta4 expression following
chronic nerve compression injury. Neuroscience Letters 465(2): 194-8; 2009 Nov 13. [Epub
2009 Sep 16] PMID: 19765400
30. Frieboes, LR; Palispis, WA; Gupta, R. Nerve compression activates selective nociceptive
pathways and up regulates peripheral sodium channel expression in Schwann cells. Journal
of Orthopaedic Research 28(6): 753-61; June, 2010. [Epub ahead of print] PMID:
20014316 Cover Image for this issue of the Journal is Figure 4 from this manuscript
31. Tapadia, M; Mozaffar, T; Gupta, R. Compressive Neuropathies of the Upper Extremity:
Update on Pathophysiology, Classification, and Electrodiagnostic Findings. Journal of Hand
Surgery 35(4): 668-677; April, 2010. [Epub 2010 Mar 11] PMID: 20223605
32. Gupta R; Bathen, ME; Smith, JS; Levi, AD; Bhatia, NN; Steward, O. Advances in the
management of spinal cord injury. Journal of the American Academy of Orthopaedic
Surgery 18(4): 210-222; April, 2010. PMID: 20357230.
33. Smith, JS; Landers, R; Pham, T; Bhatia, N; Steward, O; Gupta, R. Role of early surgical
decompression of the intradural space after cervical spinal cord injury in an animal model.
Journal of Bone and Joint Surgery 92(5):1206-1214; May, 2010. PMID: 20439667.
34. Rowshan, K; Hadley, S; Caiozzo, VJ; Lee, TQ; Gupta, R. Development of fatty atrophy after
neurologic and rotator cuff injuries in an animal model of rotator cuff pathology. Journal of
Bone and Joint Surgery 92(13): 2270-8; October, 2010. PMID: 20926720
35. Kang, J; Zamorano, DP; Gupta, R. Challenges of Limb Salvage with Major Nerve Injuries:
Current Management and Future Directions. Journal of American Academy of Orthopaedic
Surgeons 19: S28-S34, 2011.
36. Gupta, R; Nassirin, N; Bathen, M; Hazel, A; Palispis, W; Mozaffar, T. Chronic nerve
compression alters Schwann cell myelin architecture in a murine model. Muscle Nerve
45(2): 231-241, February 2012. PMID: 22246880
37. Kang, J and Gupta, R. Mechanisms of Fatty Degeneration in Massive Rotator Cuff Tears.
Journal of Shoulder and Elbow Surgery 21(2): 175-180; February, 2012. PMID: 22244060
38. Lin, MY; Palispis, W; Forootan, M; Gall, CM; Steward, O; Gupta, R. Biophysical stimuli
induce demyelination via an integrin dependent mechanism. Annals of Neurology
72(1):112-23; July, 2012. PMID: 22829273
39. Chao T, Frump D, Lin M, Caiozzo VJ, Mozaffar T, Steward O, Gupta R. Matrix
metalloproteinase 3 deletion Preserves Denervated Motor Endplate after Traumatic Nerve
Injury. Annals of Neurology 73(2): 210-23; Feb, 2013. doi: 10.1002/ana.23781. Epub 2012
Dec 31. PMID: 23281061
40. Rafijah, G; Bowen, A; Dolores, C; Vitali, R; Mozaffar, T; Gupta, R. The Use of Fibrin Glue
to Augment Nerve Repairs Does Not Impede Neural Regeneration in an Animal Model for
Segmental Nerve Defects in an Animal Model for Segmental Nerve Defects. Journal of
Hand Surgery 38(5): 847-855, May 2013. doi: 10.1016/j.jhsa.2013.01.044. Epub 2013 Apr
3. PMID: 23561728
41. Berrocal YA, Almeida VW, Gupta R, Levi AD. Transplantation of Schwann cells in a
collagen tube for the repair of large, segmental peripheral nerve defects in rats. Journal of
Neurosurgery. 119(3): 720-32; 2013 Sep. PMID: 23746104
42. Lin, MY; Manzano, G, Gupta R. Nerve conduits and allograft in peripheral nerve repair.
Hand Clinics 29(3): 331-348; August, 2013.
43. Jung, J; Hahn, P; Choi, B; Mozaffar, T; Gupta, R. Early but not Late Surgical
Decompression Restores Neurovascular Blood Flow and Ischemic Parameters in an Invivo
Animal model of Chronic Nerve Compression Injury. Journal of Bone & Joint
Surgery 96A (11): 897-906, June 4, 2014. PMID: 24897737
44. Kurimoto, S; Jung, JS; Tapadia, Lengfeld, J; Agalliu, D; Waterman,M; Mozaffar, T;
Gupta, R. Activation of the Wnt/β-catenin Signaling Cascade After Traumatic Nerve
Injury. Neuroscience 294: 101-8; May 21, 2015. doi:
10.1016/j.neuroscience.2015.02.049. Epub 2015 Mar 3. PMID: 25743255
45. Jung, J; Frump, D; Su, J; Wang, W; Mozaffar, T; Gupta, R. Desert Hedgehog is a Critical
Mediator of Demyelination in Compression Neuropathies. Experimental Neurology
271:84-94; May 1, 2015. doi: 10.1016/j.expneurol.2015.04.014. PMID: 25936873
46. Palispis W and Gupta, R. Surgical Repair in Humans After Traumatic Nerve Injury
Provides Limited Functional Neural Regeneration in Adults. Experimental Neurology
290:106-114, April, 2017. PMID: 28111229
47. Zhu D, and Gupta, R. Attenuation of Robust Glial Scar Formation Facilitates Functional Recovery in Animal Models of Chronic Nerve Compression Injury. J Bone Joint Surg Am. 2017 Dec 20;99(24):e132. doi: 10.2106/JBJS.17.00396.